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KMID : 1114620050020020136
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Journal of the Korean Society for Breast Screening
2005 Volume.2 No. 2 p.136 ~ p.143
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Immunohistochemical and Clinicopathologic Characteristics of Invasive Ductal Carcinoma of Breast with Micropapillary Carcinoma Component
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Kim Mi-Jung
Gong Gyung-Yub
Joo Hee-Jae
Ahn Sei-Hyun
Kim Hak-Hee
Kim Sung-Bae
Ro Jae Y.
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Abstract
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Purpose: To compare clinicopathologic and immunohistochemical findings between invasive breast carcinoma with MC component (IMC) and invasive breast carcinoma without MC component (NIMC).
Materials and Methods: Two hundred fifty five consecutive cases of invasive ductal carcinoma were selected from the surgical pathology files between July 1989 and Jan 1994 at Asan Medical Center. Hematoxylin and eosin (H&E)-stained slides were reviewed by two pathologists and 38 cases of IMC and 217 cases of NIMC were identified. We constructed tissue microarray from 38 cases of IMC and performed immunohistochemical stainings for cytokeratin (CK)7, CK20, estrogen receptor (ER), progesterone receptor (PR),p53, c-erb B2, and CD34 in both MC and non-MC components.
Results: Cases with IMC were associated with greater tumor size, more frequent lymphovascular invasion, nodal metastases, greater mean numbers of positive lymph nodes, and higher stage than those with NIMC, but not associated with poorer survival rates. On immunohistochemistry, only p53 reactivity was statistically different between MC and non-MC in IMC cases. ER positivity tended to be lower in MC than non-MC, but the difference was not significant.
Conclusion: Based on the frequent nodal metastases and association with higher stage of IMC than NIMC cases as well as higher p53 positivity and lower frequency of ER expression, MC could be an aggressive histologic type of breast carcinomas.
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KEYWORD
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Micropapillary carcinoma, Breast, Immunohistochemical staining
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